Genetics Home > Klinefelter Syndrome

What Is the Prognosis?

The prognosis of Klinefelter syndrome is good, provided the patients have careful and consistent monitoring of their health and early identification and treatment of any problems that occur. Many men with Klinefelter syndrome lead full and active lives, and can expect a normal lifespan.
(Click Prognosis of Klinefelter Syndrome for more information.)

History of Klinefelter Syndrome

In 1942, Dr. Harry Klinefelter and his coworkers at the Massachusetts General Hospital in Boston published a report about 9 men who had enlarged breasts, sparse facial and body hair, small testes, and an inability to produce sperm.
By the late 1950s, researchers discovered that men with Klinefelter syndrome, as this group of symptoms came to be called, had a different chromosomal arrangement, XXY, instead of the usual male arrangement, XY.
(Click History of Klinefelter Syndrome for more information.)

Other Names for Klinefelter Syndrome

Other names for Klinefelter syndrome include:
  • Klinefelter's syndrome
  • 47,XXY
  • XXY syndrome
  • XXY trisomy.
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Last reviewed by: Arthur Schoenstadt, MD
Last updated/reviewed:
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